hrp0089p1-p212 | Pituitary, Neuroendocrinology and Puberty P1 | ESPE2018

Real-World Safety Data in a Cohort of Children with Noonan Syndrome Treated with GH: Final Results from NordiNet International Outcome Study (IOS) and ANSWER Program

Juliusson Petur Benedikt , Dahlgren Jovanna , Abuzzahab M Jennifer , Pedersen Birgitte Tonnes , Roehrich Sebastian , Romano Alicia

Objectives: Current safety data do not indicate an association of GH therapy with increased risk for development/progression of tumours, or worsening of congenital cardiac conditions in individuals with Noonan syndrome (NS); however, data are limited. This report describes real-world safety data on GH therapy in paediatric patients with NS.Methods: Two complementary non-interventional, multicentre studies, NordiNet IOS (NCT00960128) and ANSWER Program (N...